CME INDIA Presentation by Admin.

Great is the Sanatan’s concept of Festival of Light

  • “It’s metamorphism, from precipitation to moisture and from cooling at night, exposes you to many types of viruses and illnesses. Because of the perfect weather, which is driven by low and humid temperatures, begins to propagate the bacteria. These bacterial populations are killed by an ignited oil lamp and chemicals from the flame. When you light up hundreds of diyas, the impact is magnified by many thousands.” – Ahuja Namrata.

The earliest mentions of Yoga in ancient Sanskrit literature, in the context of Self-development and meditation.

तं दुर्दर्शं गूढमनुप्रविष्टं
गुहाहितं गह्वरेष्ठं पुराणम् ।
अध्यात्मयोगाधिगमेन देवं
मत्वा धीरो हर्षशोकौ जहाति ॥ १२ ॥

He (the Atman), difficult to be seen, full of mystery,
the Ancient, primaeval one, concealed deep within,
He who, by yoga means of meditation on his self, comprehends Atman within him as God,
He leaves joy and sorrow far behind.

Life of bliss and liberation

  • The Katha Upanishad asserts that one who does not use his powers of reasoning, whose senses are unruly and mind unbridled, his life drifts in chaos and confusion, his existence entangled in samsara (World). Those who use their intelligence, have their senses calm and under reason, they live a life of bliss and liberation, which is the highest place of Vishnu.

Rise, awake!

उत्तिष्ठत जाग्रत
प्राप्य वरान्निबोधत ।
क्षुरस्य धारा निशिता दुरत्यया
दुर्गं पथस्तत्कवयो वदन्ति ॥ १४ ॥

– Katha Upanishad, 1.3.14   Rise, awake!

Rise, awake!
Having obtained these boons, understand them!
Like the Razor’s sharp edge is difficult to traverse,
The path to one’s Self is difficult.

Changing the world of Medicine

Next generation of mRNA vaccinology

  • Advancements in the generation, purification and cellular delivery of RNA have enabled the development of RNA therapies across a broad array of applications
  • The technology is cost-effective and relatively simple to manufacture.

PSMA-targeted therapy.

  • Prostate-specific membrane antigen (PSMA), found in high levels on the surface of prostate cancer cells, is a potential biomarker of the disease.
  • PSMA PET uses a radioactive tracer to locate and attach to PSMA proteins, making them visible by PET imaging.

New treatment for the reduction of LDL

  • Inclisiran is an injectable, chemically synthesized small interfering RNA that targets the PCSK9 protein.
  • It requires infrequent dosing (twice per year) and provides effective and sustained LDL-C reduction in conjunction with statins.
  • Its prolonged effect may help alleviate medication noncompliance, one of the leading causes of failure to lower LDL-C levels.
  • Inclisiran was approved by the FDA in December 2021 and is widely considered a game changer for heart disease patients.

Novel drug for treatment of type 2 diabetes

Breakthrough treatment for postpartum depression.

  • In 2019, the FDA approved an intravenous infusion treatment to treat postpartum depression specifically.
  • This novel therapy, administered around the clock for 60 hours, uses a neurosteroid to control the brain’s response to stress. This treatment design is ground-breaking as it targets the signaling thought to be deficient in hormone-sensitive postpartum depression.
  • This rapid treatment option would be a breakthrough for women with this often-overlooked condition.

Targeted Myosin Inhibitor for hypertrophic cardiomyopathy

  • A first-in-class medication specifically targets heart muscle to reduce abnormal contractions caused by genetic variants that put the heart into overdrive.
  • By acting specifically on this mechanism in HCM patients, this novel treatment not only improves symptoms and quality of life, but potentially could slow progression of the disease.

Nonhormonal alternatives for treating menopausal hot flashes

  • A new group of nonhormonal drugs, called NK3R antagonists, has emerged as a viable alternative to hormone therapy.
  • They have shown promise in clinical trials for relieving moderate to severe menopausal hot flashes as effectively as hormones.

Implantable for severe paralysis.

  • Implanted brain-computer interface technology is on the way to recover lost motor control and enable patients to control digital devices.
  • The technology uses implanted electrodes to collect movement signals from the brain and decode them into movement commands.
  • FDA has designated the implantable a “breakthrough device,” reinforcing the need to move this novel technology to the bedside of patients who need it most.

Artificial intelligence for early detection of sepsis

  • Artificial intelligence (AI) has emerged as a new tool to help rapidly detect sepsis.
  • Using AI algorithms, the tool detects several key sepsis risk factors in real time by monitoring patients’ electronic medical records as physicians input information.

Predictive analytics & hypertension

  • AI now can allow physicians to predict cardiovascular morbidities and intervene before they occur.
  • Predictive analytics may be the key to preventing hypertension and many other diseases.

3D printing

  • 3D printers can be now used in healthcare.
  • These game-changing printers can be used to create implants and even joints to be used during surgery.
  • 3D-printed prosthetics are increasingly using 3D printing for presurgical planning is also gaining momentum.
  • Using a realistic replica of an actual patient’s anatomy is allowing surgeons to attempt procedures they wouldn’t have previously been able to do.
  • 3D printing can be used to ‘print’ pills that contain multiple drugs, which will help patients with the organisation, timing, and monitoring of multiple medications.

Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)

  • It is the most advanced gene-editing technology.
  • It works by harnessing the natural mechanisms of the immune systems of bacterium cells of invading viruses, which is then able to ‘cut out’ infected DNA strands.
  • CRISPR is also looking promising for treating rare diseases like Cystic fibrosis (CF), sickle cell disease.



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