CME INDIA Presentation by ⚜ Dr. M. Gowri Sankar, MD, Senior Assistant Professor, Dept. of General Medicine, Government Medical College and ESI Hospital, Coimbatore.

Today’s History Feature:

Dr. Irwin Allan Rose

(Jul 16, 1926 – Jun 2, 2015)

💠American Biologist

His contributions…

🔸Irwin Rose was born in Brooklyn, New York. During his young days, he spent his summer holidays by helping out in the ward at a local hospital.

🔸During Second World War, he also served in the U.S Navy. After the war, he received his Bachelor of Science and completed his Ph.D. in Biochemistry in 1952 from the University of Chicago.

🔸Then he served as a faculty at Yale School of Medicine and then joined at Fox Chase Cancer Centre, Philadelphia in 1963 and served there until his retirement in 1995.

🔸While working in the Cancer centre, Dr. Rose along with two Israel scientists Dr. Aaron Ciechanover and Dr. Avram Hershko, made an epoch-making discovery of Ubiquitin regulatory protein.

🔸It is named Ubiquitin from the Latin word Ubique meaning “Everywhere,” because it is seen in the cells of all humans, animals and plants.

🔸Further they demonstrated that ubiquitin mediated protein degradation, which helps to control the critical biochemical processes such as cell division, the repair of defects in DNA and gene transcription.

🔸For the ground-breaking discovery of Ubiquitin-mediated protein degradation, all the three scientist were honoured with Nobel Prize of Chemistry in 2004.

🔸Ultimately, their discoveries lead to the development of drugs to combat Parkinson’s and Alzheimer’s disease, cystic fibrosis and cervical cancer.

A Day to Commemorate…

An Energetic & Enthusiastic Researcher

Dr. Irwin Allan Rose 🙏🏼


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