CME INDIA Presentation by Dr. N.K. Singh, MD, FICP, Director, Diabetes and Heart Research Centre, Dhanbad, Jharkhand, India. Editor, www.cmeindia.in.

Science has boosted and transformed our living standards. It has enabled humans to travel into unknown universe. We have new ways of thinking about ourselves and the universe.

What is Synchronicity?

  • It is a concept first introduced by analytical psychologist Carl G. Jung “to describe circumstances that appear meaningfully related yet lack a causal connection.”
  • We have realised that science is not enough for survival. Our body is controlled by so many artistic and circadian influences.
  • We need to Integrate the temporal axis into human physiology and medicine offers an opportunity to optimize the alignment of our internal rhythms to the environment.
  • If we fail to tune to new opportunities for lifestyle and pharmacological interventions to treat diseases and promote health, perfect health becomes a distant dream.
  • Our Festivals are a unique opportunity to balance gracefully with nature. These do open the fourth dimension, i.e., spirituality. We also need to heal our circadian rhythm.

What Festival of colour Holi tells ?

  • It brings awareness of the Legend of demon King Hiranya Kashyap and his son Prahlad and sister Holika
  • Spring Season is a period between end of winter and the advent of summer. This transition period induces the growth of bacteria in the atmosphere as well as in the body.
  • You go to burn Holika.
  • Following the tradition, you perform Parikrama (go around the bonfire/pyre), the heat coming from the bonfire kills the bacteria in the body and cleanses it.
  • Phagua, as traditionally said, brings laziness. People sing songs. You dance to the tune of Phag and Jogira. Dhol beating and rhythmic oscillations rejuvenate both mind and body. Science of SANATAN is unsurpassed and soothing for mankind.
  • Colours play vital role in fitness of human body.
  • In ancient times, people started playing Holi with colours made from natural sources like turmeric, Neem, Palash (Tesu) etc.
  • There is evidence of the playful pouring and throwing of colour powders made from these substances improving vitality.

Why you need to tune your Circadian clocks?

  • We know that endogenous oscillators control 24-h physiological and behavioural processes.
  • The central circadian clock exerts control over myriad aspects of mammalian physiology. It regulates sleep, metabolism, and the immune system.
  • Now we have more insights on clock genes that control rhythms in physiology and behaviour.
  • Are you aware that the circadian clock genes were among the first genes to be identified as controlling behaviour?
  • Recent studies have clearly shown that disruption of circadian rhythms is associated with sleep disorders, cancer, susceptibility to infections, metabolic syndrome, Alzheimer’s disease and aging.

Courtsey: Genomics of circadian rhythms in health and disease. Filipa Rijo-Ferreira & Joseph S. Takahashi Genome Medicine volume 11,Article number: 82 (2019)

Courtsey: Genomics of circadian rhythms in health and disease. Filipa Rijo-Ferreira & Joseph S. Takahashi Genome Medicine volume 11,Article number: 82 (2019)

Circadian Rhythm and Health issues

Human circadian sleep disorders and their genetic causes
Circadian genomics and sleep regulation
Circadian control of metabolism
Dietary influences on circadian enhancers
Adipocyte differentiation
Autophagy and circadian rhythm
Circadian control of the immune system
Immune cell trafficking
Clock regulation of innate and adaptive immunity
Host–pathogen interactions are also subjected to circadian modulation.
Infections or the resulting inflammation can also disrupt the circadian clock by dramatically decreasing the amplitude of circadian rhythms
Commensal microbiota and circadian rhythm
Cicadian rhythm in causation of cardiovascular diseases
There is a link between the circadian clock and atherosclerosis
Circadian rhythm in nervous system
The blood–brain barrier (BBB) is highly selective as to what it allows into the brain, and its permeability is regulated (in part) by the circadian clockircadian rhythmicity
Effects of light and colour in mood and learning
Circadian disruption can cause in cancer
Disruption of circadian rhythm

Courtsey: Vainshelbaum, N.M.; Salmina, K.; Gerashchenko, B.I.; Lazovska, M.; Zayakin, P.; Cragg, M.S.; Pjanova, D.; Erenpreisa, J. Role of the Circadian Clock “Death-Loop” in the DNA Damage Response Underpinning Cancer Treatment Resistance. Cells 2022, 11, 880. https://doi.org/10.3390/cells11050880

What to do in Holi?

  • It is a great occasion to remove negativity.
  • It is an opportunity for social networking, which has been found essential for neuronal health.
  • It is in tune with nature to dance, sing and enjoy.
  • Use natural colours and natural ways of celebration.
  • Will it tune synchronicity to heal circadian rhythm? – Yes.

Courtsey: Genomics of circadian rhythms in health and disease. Filipa Rijo-Ferreira & Joseph S. Takahashi Genome Medicine volume 11,Article number: 82 (2019)

New Happenings

  1. Body composition is regulated by the gut microbiota via the transcription factor NFIL3. This is a circadian basic leucine zipper transcription factor. It is important in regulating susceptibility to bowel infection and lipid metabolism.
  2. Alzheimer’s disease (AD is associated with the production and deposition of the βamyloid (Aβ) peptide, and soluble Aβ levels exhibit robust daily oscillations in mouse hippocampal interstitial fluid. But at present, little is known about how circadian rhythms may influence AD.
  3. Circadian research, in particular the concept of chrono-pharmacology, is increasingly shaping future research and medicine.

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References:

  1. MacDonald DA, Friedman HL, Brewczynski J, et al. Spirituality as a scientific construct: testing its universality across cultures and languages. PLoS One. 2015;10(3):e0117701. Published 2015 Mar 3. doi:10.1371/journal.pone.0117701
  2.  George LK, Larson DB, Koenig HG, McCullough ME (2000) Spirituality and health: What we know, what we need to know. J Soc Clin Psychol 19: 102–116
  3. Ruben MD, Wu G, Smith DF, Schmidt RE, Francey LJ, Lee YY, et al. A database of tissue-specific rhythmically expressed human genes has potential applications in circadian medicine. Sci Transl Med. 2018;10:doi: https://doi.org/10.1126/scitranslmed.aat8806.
  4. Rijo-Ferreira, F., Takahashi, J.S. Genomics of circadian rhythms in health and disease. Genome Med 11, 82 (2019). https://doi.org/10.1186/s13073-019-0704-0
  5. Vainshelbaum, N.M.; Salmina, K.; Gerashchenko, B.I.; Lazovska, M.; Zayakin, P.; Cragg, M.S.; Pjanova, D.; Erenpreisa, J. Role of the Circadian Clock “Death-Loop” in the DNA Damage Response Underpinning Cancer Treatment Resistance. Cells 2022, 11, 880. https://doi.org/10.3390/cells11050880



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